Health and Healthcare
Sutro Bio's Ovarian Cancer Treatment Ready for the Next Level
Published:
Sutro Biopharma Inc. (NASDAQ: STRO) made a huge gain to close out the week after the firm provided an update from its ongoing dose-escalation in its ovarian cancer trial.
In terms of the specifics, the data comes from the Phase 1 study of STRO-002, a folate receptor alpha (FolRα) targeting antibody-drug conjugate, for patients with ovarian cancer.
The dose-escalation portion of the study was fully enrolled with 39 patients in August 2020. Patients were heavily pretreated and had a median of six prior lines of therapy.
Results out of 31 evaluable patients included:
- 10 patients met RECIST criteria for response. Of which, 1 patient achieved a complete response (CR) and 9 patients achieved a partial response (PR). Of the PRs, 3 were confirmed PRs (cPRs) and 6 unconfirmed PRs (uPRs)
- 23 patients (74%) achieved disease control at 12 weeks
- 18 patients (58%) achieved disease control at 16 weeks
- 4 patients (13%) were on treatment for 52 weeks. 3 patients remained on treatment beyond 64 weeks
As it stands, the treatment continues to be well tolerated, and 86% of all treatment-emergent adverse events were grade 1 or 2. The most common grade 3 and 4 adverse events were reversible neutropenia.
Management noted that the women in the study were heavily pretreated and have limited treatment options, as many have received experimental agents and participated in other clinical trials.
Looking ahead, the broad therapeutic index of STRO-002 should allow for long-term dosing and dose intensity. Although a maximum tolerated dose was not reached, the firm has identified dose levels of 4.3 and 5.2 mg/kg that it plans to randomize in the dose-expansion. Sutro plans to dose the first patient January 2021 and will be treating less heavily pretreated ovarian cancer patients.
Sutro Biopharma stock traded up 37% to $23.33 on Friday, in a 52-week range of $6.00 to $23.50. The consensus price target is $21.57.
24/7 Wall St.The Average American Is Losing Their Savings Every Day (Sponsor)
If you’re like many Americans and keep your money ‘safe’ in a checking or savings account, think again. The average yield on a savings account is a paltry .4% today, and inflation is much higher. Checking accounts are even worse.
Every day you don’t move to a high-yield savings account that beats inflation, you lose more and more value.
But there is good news. To win qualified customers, some accounts are paying 9-10x this national average. That’s an incredible way to keep your money safe, and get paid at the same time. Our top pick for high yield savings accounts includes other one time cash bonuses, and is FDIC insured.
Click here to see how much more you could be earning on your savings today. It takes just a few minutes and your money could be working for you.
Thank you for reading! Have some feedback for us?
Contact the 24/7 Wall St. editorial team.
Latest from 24/7
