The stock market is mixed Tuesday, with the Dow Jones Industrial Average up 0.27%, the Nasdaq down 0.35% and the S&P 500 up 0.13%. Today’s winners are a biopharmaceutical company that continues to see its shares rise on a positive drug trial result and an oil company with a major shareholder that plans to nominate directors to boost returns. Today’s losers are a technology company reporting a poor 2013 outlook and another pharmaceutical company reporting disappointing trial results for a treatment.

These are Tuesday’s market winners and losers.

Biggest Winners

Shares of Keryx Biopharmaceuticals Inc. (NASDAQ: KERX) are up 37.05% on trading volume of 24.2 million shares. The stock continues to jump after positive reports regarding the company’s kidney drug. Before Tuesday, the 52-week high was $6.86.

Shares of Hess Corp. (NYSE: HES) are up 9.33% to $68.31 on trading volume of 10.3 million shares. Elliott Management announced it plans to nominate five executives to the board to help boost shareholder returns. Before Tuesday, the 52-week high was $67.86.

Biggest Losers

Shares of VMWare Inc. (NYSE: VMW) are down 19.66% to $78.99 on trading volume of 13.1 million shares. The company announced in its fourth-quarter earnings presentation that it would likely earn $1.85 a share, below the $1.90 expected by analysts polled by Reuters. Before Tuesday, the 52-week low was $79.46.

Shares of Anacor Pharmaceuticals Inc. (NASDAQ: ANAC) are down 17.79% to $4.25 on trading volume of 4.2 million shares. The shares fell following disappointing results on a test for toenail fungus therapy. Before Tuesday, the 52-week low was $4.50.

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