INSM Q3 2025 Earnings
Reported Oct 30, 2025 at 7:00 AM ET · SEC Source
Q3 25 EPS
$-1.75
MISS 28.02%
Est. $-1.37
Q3 25 Revenue
$142.3M
BEAT +23.25%
Est. $115.5M
vs S&P Since Q3 25
-34.2%
TRAILING MARKET
INSM -28.2% vs S&P +6.0%
Market Reaction
Did INSM Beat Earnings? Q3 2025 Results
Insmed delivered a strikingly mixed Q3 2025, with revenue soaring 52.4% year over year to $142.34 million, well ahead of the $115.49 million consensus, while its per-share loss of $1.75 missed the $-1.37 estimate by 28.02% as the company absorbed the… Read more Insmed delivered a strikingly mixed Q3 2025, with revenue soaring 52.4% year over year to $142.34 million, well ahead of the $115.49 million consensus, while its per-share loss of $1.75 missed the $-1.37 estimate by 28.02% as the company absorbed the heavy costs of launching its newly approved BRINSUPRI. The FDA-approved DPP1 inhibitor, the first treatment authorized for non-cystic fibrosis bronchiectasis, generated $28.10 million in net sales during its partial debut quarter, drawing roughly 2,550 patients and prescriptions from approximately 1,700 physicians, though management noted that inventory stocking accounted for about 40% of those sales and is unlikely to repeat at that level in Q4. ARIKAYCE, meanwhile, posted $114.30 million in quarterly revenue, up 22% year over year, prompting Insmed to raise its full-year ARIKAYCE guidance to $420 million–$430 million. Total operating expenses climbed to $508.35 million, driven by a $104.65 million fair-value charge and near-doubling SG&A costs, widening the net loss to $370.02 million. With a positive EMA recommendation already secured and regulatory submissions accepted in the UK and Japan, international BRINSUPRI launches in 2026 represent the next major commercial catalyst for the company.
Key Takeaways
- • FDA approval and U.S. launch of BRINSUPRI drove new revenue stream ($28.1M in partial quarter)
- • ARIKAYCE global revenue grew 22% YoY with record quarterly results in both U.S. and international markets
- • International ARIKAYCE business grew 52% YoY driven by expansion across all geographic regions
- • ~2,550 patients started BRINSUPRI treatment and ~1,700 physicians wrote prescriptions in the partial quarter
INSM YoY Financials
Q3 2025 vs Q3 2024, source: SEC Filings
INSM Revenue by Segment
With YoY comparisons, source: SEC Filings
INSM Revenue by Geography
With YoY comparisons, source: SEC Filings
“The third quarter of 2025 celebrated the FDA approval of BRINSUPRI and the availability of our second commercial product, underscoring our team's dedication to bringing forward a first-in-disease therapy for patients with non-cystic fibrosis bronchiectasis. While still early in the U.S. BRINSUPRI launch, we are very encouraged by positive feedback received from both physicians and patients.”
— Will Lewis, Q3 2025 Earnings Press Release
INSM Earnings Trends
INSM vs Market 30 Day Price Reactions
30-day stock return vs benchmark after each earnings
INSM EPS Trend
Earnings per share: estimate vs actual
INSM Revenue Trend
Quarterly revenue: estimate vs actual
INSM Quarterly Results
4 quarters of earnings data
| Quarter | EPS Est. | EPS Act. | Surprise | Revenue | Rev. Surprise |
|---|---|---|---|---|---|
| Q1 26 MISS FY | $-1.17 | $-1.54 | -31.62% | $263.8M | — |
| FY Full Year | $-5.87 | — | — | — | — |
| Q3 25 MISS | $-1.37 | $-1.75 | -28.02% | $142.3M | +23.25% |
| Q2 25 MISS | $-1.31 | $-1.70 | -29.59% | $107.4M | +2.97% |
| Q1 25 MISS | $-1.36 | $-1.42 | -4.36% | $92.8M | +0.80% |