Insmed

INSM Q3 2025 Earnings

Reported Oct 30, 2025 at 7:00 AM ET · SEC Source

Q3 25 EPS

$-1.75

MISS 28.02%

Est. $-1.37

Q3 25 Revenue

$142.3M

BEAT +23.25%

Est. $115.5M

vs S&P Since Q3 25

-34.2%

TRAILING MARKET

INSM -28.2% vs S&P +6.0%

Market Reaction

Did INSM Beat Earnings? Q3 2025 Results

Insmed delivered a strikingly mixed Q3 2025, with revenue soaring 52.4% year over year to $142.34 million, well ahead of the $115.49 million consensus, while its per-share loss of $1.75 missed the $-1.37 estimate by 28.02% as the company absorbed the… Read more Insmed delivered a strikingly mixed Q3 2025, with revenue soaring 52.4% year over year to $142.34 million, well ahead of the $115.49 million consensus, while its per-share loss of $1.75 missed the $-1.37 estimate by 28.02% as the company absorbed the heavy costs of launching its newly approved BRINSUPRI. The FDA-approved DPP1 inhibitor, the first treatment authorized for non-cystic fibrosis bronchiectasis, generated $28.10 million in net sales during its partial debut quarter, drawing roughly 2,550 patients and prescriptions from approximately 1,700 physicians, though management noted that inventory stocking accounted for about 40% of those sales and is unlikely to repeat at that level in Q4. ARIKAYCE, meanwhile, posted $114.30 million in quarterly revenue, up 22% year over year, prompting Insmed to raise its full-year ARIKAYCE guidance to $420 million–$430 million. Total operating expenses climbed to $508.35 million, driven by a $104.65 million fair-value charge and near-doubling SG&A costs, widening the net loss to $370.02 million. With a positive EMA recommendation already secured and regulatory submissions accepted in the UK and Japan, international BRINSUPRI launches in 2026 represent the next major commercial catalyst for the company.

Key Takeaways

  • FDA approval and U.S. launch of BRINSUPRI drove new revenue stream ($28.1M in partial quarter)
  • ARIKAYCE global revenue grew 22% YoY with record quarterly results in both U.S. and international markets
  • International ARIKAYCE business grew 52% YoY driven by expansion across all geographic regions
  • ~2,550 patients started BRINSUPRI treatment and ~1,700 physicians wrote prescriptions in the partial quarter
24/7 Wall St

INSM YoY Financials

Q3 2025 vs Q3 2024, source: SEC Filings

24/7 Wall St

INSM Revenue by Segment

With YoY comparisons, source: SEC Filings

Q1 25 Q1 26
24/7 Wall St

INSM Revenue by Geography

With YoY comparisons, source: SEC Filings

Q1 25 Q1 26

“The third quarter of 2025 celebrated the FDA approval of BRINSUPRI and the availability of our second commercial product, underscoring our team's dedication to bringing forward a first-in-disease therapy for patients with non-cystic fibrosis bronchiectasis. While still early in the U.S. BRINSUPRI launch, we are very encouraged by positive feedback received from both physicians and patients.”

— Will Lewis, Q3 2025 Earnings Press Release