The short interest data are out for the April 15 settlement date. Biotech companies are considered a riskier group of stocks, with big upside and big downside. FDA rulings can make or break them. A single failed clinical trial can mean disaster for a stock. 24/7 Wall St. has reviewed the top biotech companies, without focusing on speculative companies.

The April 15 short interest data have been compared with the previous report, and short interest decreased across the board in these selected stocks.

Amgen Inc. (NASDAQ: AMGN) saw its short interest fall to 8.85 million shares from the previous level of 9.71 million. Shares closed most recently at $162.85, in a 52-week trading range of $130.09 to $181.81.

Biogen Inc. (NASDAQ: BIIB) had a short interest decrease to 2.12 million shares from the previous level of 2.52 million. Shares closed Tuesday at $281.70, within a 52-week range of $242.07 to $420.99.

Celgene Corp. (NASDAQ: CELG) short interest for this settlement date decreased to 8.46 million shares from the previous 9.99 million. Shares of Celgene closed most recently at $107.55, in a 52-week range of $92.98 to $140.72.

Gilead Sciences Inc. (NASDAQ: GILD) saw its short interest fall to 26.68 million shares from 29.07 million in the previous period. Shares closed Tuesday at $101.33, in a 52-week trading range of $81.89 to $123.37.

MannKind Corp. (NASDAQ: MNKD) saw its short interest decrease to 103.74 million shares. The previous reading was 112.04 million. Shares closed most recently at $1.62, in a 52-week trading range of $0.64 to $7.32.

Alexion Pharmaceuticals Inc. (NASDAQ: ALXN) short interest increased to 5.80 million, compared to the previous level of 5.38 million. Shares closed most recently at $154.01, in a 52-week range of $124.16 to $208.88.

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