Our Strongest Conviction Call: Eli Lilly Headed 21% Higher in 12 Months

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By Vandita Jadeja Updated Published

Quick Read

  • Eli Lilly (LLY) reported Q1 revenue of $19.80B (up 55.5% YoY) and non-GAAP EPS of $8.55 (26% above consensus), with Mounjaro generating $8.66B and Zepbound contributing $4.16B, while the company raised full-year guidance to $82B-$85B in revenue and $35.5-$37 in EPS.

  • Eli Lilly’s shares are down 12.89% year to date despite blockbuster earnings, creating a valuation gap that 24/7 Wall St. projects can close as Foundayo, the only oral GLP-1 pill approved for flexible dosing, scales the obesity market beyond injectable competitors.

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Our Strongest Conviction Call: Eli Lilly Headed 21% Higher in 12 Months

© 24/7 Wall St.

Eli Lilly (NYSE:LLY | LLY Price Prediction) just delivered one of the strongest first quarters in big pharma history, but shares have pulled back sharply from their February peak. That gap between operating performance and stock price is where our model sees opportunity.

Our 24/7 Wall St. price target for Eli Lilly is $1,133.12 over the next 12 months, implying 21.24% upside from the current price of $934.60. Our recommendation is buy with a 90% confidence rating, our highest tier.

An infographic titled 'Eli Lilly and Company (LLY) 12-Month Price Prediction.' It shows a current price of $934.60 as of 05/01/2026, an upside of +21.24%, and a price target of $1,133.12, with a 'BUY' recommendation and 'High Confidence (90%)'. The 'How We Got There' section lists Analyst Consensus ($1,202.34, 30% Weight), Forward P/E-Based Price ($915.61), and Trailing P/E-Based Price ($934.60), leading to a Weighted Base of $1,005.43. 'Our Adjustments (247Factor: 1.127)' includes positive contributions from Earnings Growth, Sector Momentum & Analyst Consensus, and Low Volatility, and a 50% reduction for Mega-cap Dampening, arriving at the Final Target of $1,133.12. The 'Bull Case' section lists Foundayo FDA Approval, Mounjaro & Zepbound Revenue Growth, and Pipeline Progress, with a Bull Case Target of $1,219.94 (+30.53% Total Return). The 'Bear Case' section lists Realized Price Declines, Acquired IPR&D Charges & Litigation Costs, and Revenue Concentration & Biosimilar Competition Risks, with a Bear Case Target of $960.71 (+2.79% Total Return). The bottom line reiterates 'BUY -> $1,133.12 (+21.24%)' with a summary text.
24/7 Wall St.

24/7 Wall St. Price Target Summary

Metric Value
Current Price $934.60
24/7 Wall St. Price Target $1,133.12
Upside 21.24%
Recommendation BUY
Confidence Level 90%

From $1,062 Peak to a Buyable Pullback

Lilly is down 12.89% year to date after peaking near $1,062 in December 2025, yet shares jumped 9.8% on April 30 following a blockbuster Q1 earnings report.

Revenue hit $19.80 billion, beating estimates by 11.25% and growing 55.5% year over year. Non-GAAP EPS came in at $8.55 versus a $6.79 consensus, a 25.88% beat. Mounjaro alone generated $8.66 billion (up 125%), and Zepbound added $4.16 billion (up 80%). Lilly raised full-year revenue guidance to $82 billion to $85 billion and EPS guidance to $35.5 to $37.

The Case for $1,219 and Higher

Bulls have plenty of fuel. CEO David Ricks called out “the U.S. FDA approval of Foundayo, the only approved GLP-1 pill that can be taken any time of day, without food and water restrictions.” An oral GLP-1 dramatically expands the addressable obesity market beyond injectables.

Retatrutide Phase 3 data showed significant A1C and weight reductions in type 2 diabetes, and Mounjaro joined China’s National Reimbursed Drug List. Four announced acquisitions (Orna, Centessa, Kelonia, Ajax) extend the pipeline into cell therapy and CAR-T.

Our bull-case scenario takes shares to $1,219.94, a 30.53% total return. Analyst consensus already sits at $1,202.34 with 24 buy ratings against one sell.

A close-up, black and white image of a human hand holding a medical syringe with a visible needle, poised against a dark, blurred background. The transparent barrel of the syringe shows measurement markings and a small amount of liquid.
Bettmann / Getty Images

The Risks Worth Watching

Realized prices fell 13% in Q1 as rebates and access agreements bit into Mounjaro and Zepbound economics. China NRDL inclusion, while expanding volume, compresses international price per dose. Lilly also booked $584 million in acquired IPR&D charges and $279 million in litigation-related charges this quarter.

Bulls would counter that volume grew 65%, more than offsetting price declines, and IPR&D charges reflect investment in tomorrow’s pipeline rather than core profit erosion. Still, revenue concentration in two GLP-1 products and looming biosimilar competition justify caution. Our bear case lands at $960.71, only 2.79% above today.

Bottom Line

The 24/7 Wall St. price target of $1,133.12 with a buy rating and 90% confidence reflects a rare setup: a mega-cap compounding earnings above 50% while shares trade 12.89% below where they started the year.

The bull thesis hinges on whether Foundayo can scale the GLP-1 category beyond injection-comfortable patients. The bear thesis centers on rebate pressure compressing gross margins faster than volume growth offsets. The risk-reward skews favorable based on our model.

Eli Lilly Price Prediction 2026-2030

Looking further ahead, here is where our 24/7 Wall St. price target model projects Lilly could trade in coming years, assuming current growth trajectories and margin guidance hold.

Year 24/7 Wall St. Price Target
2026 $1,133.12
2030 $1,674.95

These projections assume Lilly continues executing on Foundayo, retatrutide, and pipeline acquisitions. Significant upside or downside could come from oral GLP-1 share gains, biosimilar timing, or further pricing concessions in major markets.

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About the Author Vandita Jadeja →

Vandita Jadeja is a financial copywriter who loves to read and write about stocks. She believes in buying and holding for long term gains. Her knowledge of words and numbers helps her write clear stock analysis. She has contributed to several publications, including the Joy Wallet, Benzinga, The Motley Fool and InvestorPlace.

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